PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress
PTEN is a tumor suppressor frequently mutated in human cancers. PTEN inhibits the phosphatidylinositol 3-kinase (PI3K)-AKT cascade, and nuclear PTEN guards the genome by multiple mechanisms. Here, we report that PTEN physically associates with the minichromosome maintenance complex component 2 (MCM2...
| Autori principali: | , , , , , , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
Elsevier
2015-11-01
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| Serie: | Cell Reports |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2211124715011705 |