Ascertaining cells’ synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries

Ascertaining cells’ synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries

Synaptic connections are critical for brain function but are hard to measure systematically. Here, authors present a method which uses rabies virus barcoding and single-cell RNAseq to parallelize monosynaptic network reconstruction from molecularly-profiled single cells.

Bibliographic Details
Main Authors: Arpiar Saunders, Kee Wui Huang, Cassandra Vondrak, Christina Hughes, Karina Smolyar, Harsha Sen, Adrienne C. Philson, James Nemesh, Alec Wysoker, Seva Kashin, Bernardo L. Sabatini, Steven A. McCarroll
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34334-1

Internet

https://doi.org/10.1038/s41467-022-34334-1

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