The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDLs⃞

The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDLs⃞

Phosphatidate phosphatase-1 (PAP-1) converts phosphatidate to diacylglycerol and plays a key role in the biosynthesis of phospholipids and triacylglycerol (TAG). PAP-1 activity is encoded by members of the lipin family, including lipin-1 (1α and 1β), -2, and -3. We determined the effect of lipin-1 e...

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Bibliographic Details
Main Authors: Maroun Bou Khalil, Meenakshi Sundaram, Hong-Yu Zhang, Philip H. Links, Jennifer F. Raven, Boripont Manmontri, Meltem Sariahmetoglu, Khai Tran, Karen Reue, David N. Brindley, Zemin Yao
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Lipid Research
Subjects:
fatty liver dystrophy
hepatosteatosis
triacylglycerol
hypertriglyceridemia
diabetes
dexamethasone
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520414683

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http://www.sciencedirect.com/science/article/pii/S0022227520414683

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