Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer’s disease

Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease that can cause dementia. We aim to screen out the hub genes involved in AD based on microarray datasets. Methods Gene expression profiles GSE5281 and GSE28146 were retrieved from Gene Expression Omnibus database...

Full description

Bibliographic Details
Main Authors:	Wenyuan Cao, Zhangge Ji, Shoulian Zhu, Mei Wang, Runming Sun
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Series:	BMC Medical Genomics
Subjects:	Alzheimer disease Gene expression profiling Protein interaction maps Computational biology
Online Access:	https://doi.org/10.1186/s12920-023-01775-6

Similar Items

Bioinformatics analysis reveals novel hub gene pathways associated with IgA nephropathy
by: Xue Jiang, et al.
Published: (2020-09-01)

Bioinformatics analysis revealed hub genes and pathways involved in sorafenib resistance in hepatocellular carcinoma
by: Jing Liu, et al.
Published: (2019-07-01)

Hub genes, diagnostic model, and predicted drugs in systemic sclerosis by integrated bioinformatics analysis
by: Yue-Mei Yan, et al.
Published: (2023-07-01)

Identification of hub genes and small-molecule compounds related to intracerebral hemorrhage with bioinformatics analysis
by: Zhendong Liu, et al.
Published: (2019-10-01)

Identifying Hub Genes and miRNAs Associated with Alzheimer’s Disease: A Bioinformatics Pathway to Novel Therapeutic Strategies
by: Elisa Gascón, et al.
Published: (2024-12-01)

CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer’s Disease Involved the cGMP-PKG Signal Pathway
by: Yuan Zhang, et al.
Published: (2021-05-01)

Identification of Differential Genes of DNA Methylation Associated With Alzheimer’s Disease Based on Integrated Bioinformatics and Its Diagnostic Significance
by: Fan Chen, et al.
Published: (2022-05-01)

Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer’s disease reveals key pathways and hub genes with potential diagnostic utility: a preliminary study
by: Kelly Cardona, et al.
Published: (2021-08-01)

Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis
by: Wenxing Su, et al.
Published: (2020-09-01)

Diagnostic models and predictive drugs associated with cuproptosis hub genes in Alzheimer's disease
by: Erdong Zhang, et al.
Published: (2023-01-01)

Alterations in mRNA level of proteins related to redox state and mitochondria in an Alzheimer’s disease animal model: Promising targets in neuroprotection
by: Sylwia Żulińska, et al.
Published: (2024-10-01)

A meta-analysis of microarray datasets to identify biological regulatory networks in Alzheimer’s disease
by: Kimia Sadat Hashemi, et al.
Published: (2023-08-01)

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease
by: Qi Zhang, et al.
Published: (2018-03-01)

Identification ferroptosis-related hub genes and diagnostic model in Alzheimer’s disease
by: Huabin Zhao, et al.
Published: (2023-10-01)

Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients
by: Callum N. Watson, et al.
Published: (2022-01-01)

Identifying the function of methylated genes in Alzheimer’s disease to determine epigenetic signatures: a comprehensive bioinformatics analysis
by: Md Rezanur Rahman, et al.
Published: (2021-01-01)

Transcriptional Dysregulation Study Reveals a Core Network Involving the Progression of Alzheimer's Disease
by: Guofeng Meng, et al.
Published: (2019-05-01)

Identification and Validation of Hub Genes with Poor Prognosis in Hepatocellular Carcinoma by Integrated Bioinformatical Analysis
by: Guo J, et al.
Published: (2022-04-01)

Integrated bioinformatics-based identification of diagnostic markers in Alzheimer disease
by: Danmei Chen, et al.
Published: (2022-11-01)

Identification of potential diagnostic biomarkers of atherosclerosis based on bioinformatics strategy
by: Zhipeng Zheng, et al.
Published: (2023-05-01)

Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease
by: Kuang-Den Chen, et al.
Published: (2011-09-01)

Identification of Hub Genes Associated with Gastric Cancer via Bioinformatics Analysis and Validation Studies
by: Zhao T, et al.
Published: (2023-10-01)

Bioinformatic Analysis and Translational Validation of Psoriasis Candidate Genes for Precision Medicine
by: Li AH, et al.
Published: (2022-07-01)

Hub Genes, Diagnostic Model, and Predicted Drugs Related to Iron Metabolism in Alzheimer's Disease
by: Xuefeng Gu, et al.
Published: (2022-07-01)

Identification of Hub Diagnostic Biomarkers and Candidate Therapeutic Drugs in Heart Failure
by: Guo Y, et al.
Published: (2022-01-01)

Development and Validation of Hub Genes for Adrenal Aldosterone-Producing Adenoma by Integrated Bioinformatics Analysis
by: Cai H, et al.
Published: (2021-12-01)

Identification of Hub Genes in Colorectal Adenocarcinoma by Integrated Bioinformatics
by: Yang Liu, et al.
Published: (2022-05-01)

The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
by: Lucrezia Cellai, et al.
Published: (2018-08-01)

Identification of novel hub genes for Alzheimer’s disease associated with the hippocampus using WGCNA and differential gene analysis
by: Yang Chen, et al.
Published: (2024-03-01)

On the horizon—the value and promise of the global pipeline of Alzheimer's disease therapeutics
by: Michael A. Cole, et al.
Published: (2020-01-01)

Identification of potential hub genes and therapeutic drugs in ovarian cancer via bioinformatics analysis
by: Xinyue Zhou, et al.
Published: (2023-12-01)

Altered functional association and couplings: Effective diagnostic neuromarkers for Alzheimer’s disease
by: Chongyi Zhao, et al.
Published: (2022-10-01)

Identification of Hub Genes Associated With Tuberculous Pleurisy by Integrated Bioinformatics Analysis
by: Lei Shi, et al.
Published: (2021-12-01)

Identification and Validation of Hub Genes Associated With Hepatocellular Carcinoma Via Integrated Bioinformatics Analysis
by: Sumei Wang, et al.
Published: (2021-06-01)

Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions
by: Stella A. Belonwu, et al.
Published: (2022-04-01)

Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer’s disease with qPCR validation
by: Fanmao Jin, et al.
Published: (2022-08-01)

Identification of hub genes with diagnostic values in pancreatic cancer by bioinformatics analyses and supervised learning methods
by: Chunyang Li, et al.
Published: (2018-11-01)

Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
by: Abdulahad Bayraktar, et al.
Published: (2023-05-01)

Identification of Potential Targets Linked to the Cardiovascular/Alzheimer’s Axis through Bioinformatics Approaches
by: Francisco Andújar-Vera, et al.
Published: (2022-02-01)

Identification and Validation of a Five-Gene Diagnostic Signature for Preeclampsia
by: Yu Liu, et al.
Published: (2022-06-01)