N-linoleyltyrosine protects neurons against Aβ1–40-induced cell toxicity via autophagy involving the CB2/AMPK/mTOR/ULK1 pathway

N-linoleyltyrosine protects neurons against Aβ1–40-induced cell toxicity via autophagy involving the CB2/AMPK/mTOR/ULK1 pathway

Beta-amyloid protein (Aβ) is one of the most important pathogenic factors of Alzheimer’s disease (AD). N-linoleyltyrosine (NITyr) was synthesized in our laboratory and exerted neuroprotective effects in APP/PS1 transgenic mice in previous reports. In this study, the neuroprotective effects and mecha...

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Bibliographic Details
Main Authors: Yi Zhou, Zi-xiang Li, Yuan-ting Liu, Ze-Cheng Xu, Yan Hu, Wen Lv, Zheng-yu Yang, Yan-mei Sheng, Sha Liu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Brain Research Bulletin
Subjects:
N-linoleyltyrosine
Cannabinoid receptor
Autophagy
Beta-amyloid protein
Neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022001940

Internet

http://www.sciencedirect.com/science/article/pii/S0361923022001940

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