Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington’s Disease

Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington’s Disease

Huntington’s disease (HD) is a hereditary neurodegenerative disease that is caused by polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular activities that is dysregulated in HD is store-operated calcium entry (SOCE), a process by which Ca2+ release from the endoplasmic retic...

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Bibliographic Details
Main Authors: Magdalena Czeredys, Vladimir A. Vigont, Vasilisa A. Boeva, Katsuhiko Mikoshiba, Elena V. Kaznacheyeva, Jacek Kuznicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Huntington’s disease
huntingtin
huntingtin-associated protein 1 isoform A
YAC128
medium spiny neurons
store-operated calcium entry
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00381/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00381/full

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