Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies

Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies

Metronomic chemotherapy (MET) has been developed to address the shortcomings of maximum-tolerated chemotherapy (MTD) in regard to toxicity and development of resistance mechanisms in the tumor. In colorectal cancer (CRC), MET is a promising novel strategy to treat locally advanced malignancies when...

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Bibliographic Details
Main Authors: Ariel I. Mundo, Abdussaboor Muhammad, Kerlin Balza, Christopher E. Nelson, Timothy J. Muldoon
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Longitudinal data
Colon cancer
Azoxymethane
Hypoxia
Vegf
Generalized additive models
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000525

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http://www.sciencedirect.com/science/article/pii/S1476558622000525

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