Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach.

Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach.

PARP-1 inhibition has been studied over the last decades for the treatment of various diseases. Despite the fact that several molecules act as PARP-1 inhibitors, a reduced number of compounds are used in clinical practice. To identify new compounds with a discriminatory PARP-1 inhibitory function, e...

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Bibliographic Details
Main Authors: Salete J Baptista, Maria M C Silva, Elisabetta Moroni, Massimiliano Meli, Giorgio Colombo, Teresa C P Dinis, Jorge A R Salvador
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5266331?pdf=render

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http://europepmc.org/articles/PMC5266331?pdf=render

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