Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon

Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon

Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chron...

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Bibliographic Details
Main Authors: Alessio Mylonas, Curdin Conrad
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
plaque psoriasis
paradoxical psoriasis
TNF
IL-23
TH17
type I-interferon
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02746/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02746/full

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