Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon
Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chron...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02746/full |
| _version_ | 1818507173646303232 |
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| author | Alessio Mylonas Curdin Conrad |
| author_facet | Alessio Mylonas Curdin Conrad |
| author_sort | Alessio Mylonas |
| collection | DOAJ |
| description | Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory diseases such as psoriasis. Although being highly effective in psoriasis treatment, anti-TNFs can themselves induce psoriasis-like skin lesions, a side effect called paradoxical psoriasis. In this review, we provide a comprehensive look at the different cellular and molecular players involved in classical plaque psoriasis and contrast its pathogenesis to paradoxical psoriasis, which is clinically similar but immunologically distinct. Classical psoriasis is a T-cell mediated autoimmune disease driven by TNF, characterised by T-cells memory, and a relapsing disease course. In contrast, paradoxical psoriasis is caused by the absence of TNF and represents an ongoing type-I interferon-driven innate inflammation that fails to elicit T-cell autoimmunity and lacks memory T cell-mediated relapses. |
| first_indexed | 2024-12-10T22:14:55Z |
| format | Article |
| id | doaj.art-c7e8c0954b4c49b9a81af6b589d020e8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T22:14:55Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c7e8c0954b4c49b9a81af6b589d020e82022-12-22T01:31:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-11-01910.3389/fimmu.2018.02746419932Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I InterferonAlessio MylonasCurdin ConradChronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory diseases such as psoriasis. Although being highly effective in psoriasis treatment, anti-TNFs can themselves induce psoriasis-like skin lesions, a side effect called paradoxical psoriasis. In this review, we provide a comprehensive look at the different cellular and molecular players involved in classical plaque psoriasis and contrast its pathogenesis to paradoxical psoriasis, which is clinically similar but immunologically distinct. Classical psoriasis is a T-cell mediated autoimmune disease driven by TNF, characterised by T-cells memory, and a relapsing disease course. In contrast, paradoxical psoriasis is caused by the absence of TNF and represents an ongoing type-I interferon-driven innate inflammation that fails to elicit T-cell autoimmunity and lacks memory T cell-mediated relapses.https://www.frontiersin.org/article/10.3389/fimmu.2018.02746/fullplaque psoriasisparadoxical psoriasisTNFIL-23TH17type I-interferon |
| spellingShingle | Alessio Mylonas Curdin Conrad Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon Frontiers in Immunology plaque psoriasis paradoxical psoriasis TNF IL-23 TH17 type I-interferon |
| title | Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon |
| title_full | Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon |
| title_fullStr | Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon |
| title_full_unstemmed | Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon |
| title_short | Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon |
| title_sort | psoriasis classical vs paradoxical the yin yang of tnf and type i interferon |
| topic | plaque psoriasis paradoxical psoriasis TNF IL-23 TH17 type I-interferon |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02746/full |
| work_keys_str_mv | AT alessiomylonas psoriasisclassicalvsparadoxicaltheyinyangoftnfandtypeiinterferon AT curdinconrad psoriasisclassicalvsparadoxicaltheyinyangoftnfandtypeiinterferon |