A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl

A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl

Summary: Poorly immunogenic small molecules pose challenges for the production of clinically efficacious vaccines and antibodies. To address this, we generate an immunization platform derived from the immunogenic surface coat of the African trypanosome. Through sortase-based conjugation of the targe...

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Bibliographic Details
Main Authors: Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan P. Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Monica Chandra, Katharina Urban, Anastasia Gkeka, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000608

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http://www.sciencedirect.com/science/article/pii/S2211124723000608

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