Chemical Chaperones Modulate the Formation of Metabolite Assemblies

Chemical Chaperones Modulate the Formation of Metabolite Assemblies

The formation of amyloid-like structures by metabolites is associated with several inborn errors of metabolism (IEMs). These structures display most of the biological, chemical and physical properties of protein amyloids. However, the molecular interactions underlying the assembly remain elusive, an...

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Bibliographic Details
Main Authors: Hanaa Adsi, Shon A. Levkovich, Elvira Haimov, Topaz Kreiser, Massimiliano Meli, Hamutal Engel, Luba Simhaev, Shai Karidi-Heller, Giorgio Colombo, Ehud Gazit, Dana Laor Bar-Yosef
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
chemical chaperones
osmolytes
hydrophobic compounds
metabolite assemblies
amyloid formation
adenine
Online Access:https://www.mdpi.com/1422-0067/22/17/9172

Internet

https://www.mdpi.com/1422-0067/22/17/9172

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