Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

Abstract Background Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human synovial tissues (ST), and its impact on the pro-inflammatory function of...

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Bibliographic Details
Main Authors: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Sandra Ergueta, Eduardo Martín, Cristina Municio, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado, José L. Pablos
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Immunity & Ageing
Subjects:
Rheumatoid arthritis
Synovial fibroblasts
Aging
Cell senescence
SASP
Online Access:http://link.springer.com/article/10.1186/s12979-019-0169-4

Internet

http://link.springer.com/article/10.1186/s12979-019-0169-4

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