BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters

BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters

Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs). P3F recruits co-regulatory fac...

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Bibliographic Details
Main Authors: Diana H. Chin, Issra Osman, Jadon Porch, Hyunmin Kim, Kristen K. Buck, Javier Rodriguez, Bianca Carapia, Deborah Yan, Stela B. Moura, Jantzen Sperry, Jonathan Nakashima, Kasey Altman, Delsee Altman, Berkley E. Gryder
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
BET bromodomains
BRD4
PAX3-FOXO1
Rhabdomyosarcoma
RNA Polymerase II
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Online Access:https://www.mdpi.com/1424-8247/16/2/199

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https://www.mdpi.com/1424-8247/16/2/199

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