Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies

Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies

Abstract Cyclooxygenase (COX) and Lipoxygenase (LOX) are essential enzymes for arachidonic acid (AA) to eicosanoids conversion. These AA-derived eicosanoids are essential for initiating immunological responses, causing inflammation, and resolving inflammation. Dual COX/5-LOX inhibitors are believed...

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Bibliographic Details
Main Authors: Mithun Rudrapal, Wafa Ali Eltayeb, Gourav Rakshit, Amr Ahmed El-Arabey, Johra Khan, Sahar M. Aldosari, Bader Alshehri, Mohnad Abdalla
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35161-0

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https://doi.org/10.1038/s41598-023-35161-0

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