Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation

Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation

Oral cancer patients have a poor prognosis, with approximately 66% of patients surviving 5-years after diagnosis. Treatments for oral cancer are limited and have many adverse side effects; thus, further studies are needed to develop drugs that are more efficacious. To achieve this objective, we deve...

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Bibliographic Details
Main Authors: Yuyang Sun, Emily K. Zboril, Jorge J. De La Chapa, Xiufang Chai, Viviane Nascimento Da Conceicao, Matthew C. Valdez, Stanton F. McHardy, Cara B. Gonzales, Brij B. Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Physiology
Subjects:
SOCE channels
Ca2+ homeostasis
TRPC1/STIM1
ER stress
mitochondrial dysfunction
and oral cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.969000/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.969000/full

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