Guanylate Binding Proteins Restrict <named-content content-type="genus-species">Leishmania donovani</named-content> Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting

Guanylate Binding Proteins Restrict <named-content content-type="genus-species">Leishmania donovani</named-content> Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting

ABSTRACT Interferon (IFN)-inducible guanylate binding proteins (GBPs) play important roles in host defense against many intracellular pathogens that reside within pathogen-containing vacuoles (PVs). For instance, members of the GBP family translocate to PVs occupied by the protozoan pathogen Toxopla...

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Bibliographic Details
Main Authors: Arun Kumar Haldar, Utsav Nigam, Masahiro Yamamoto, Jörn Coers, Neena Goyal
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
Leishmania
nonphagocytic cells
guanylate binding proteins
GBP
GTPases
IRGM
Online Access:https://journals.asm.org/doi/10.1128/mBio.01464-20

Internet

https://journals.asm.org/doi/10.1128/mBio.01464-20

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