Studies on the prenatal diagnosis of spinal muscular atrophy by multiplex ligation⁃dependent probe amplification

Studies on the prenatal diagnosis of spinal muscular atrophy by multiplex ligation⁃dependent probe amplification

Objective To investigate the value of multiplex ligation⁃dependent probe amplification (MLPA) method in the prenatal diagnosis of spinal muscular atrophy (SMA). Methods Six SMA pedigrees, which included 7 patients, 12 parents and 6 fetuses, were admitted in our hospital. MLPA was used to detect the...

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Bibliographic Details
Main Authors: Ya⁃fang CHEN, Jin HE, Qi⁃jie ZHANG, Xiang LIN, Ning WANG, Wan⁃jin CHEN
Format: Article
Language:English
Published: Tianjin Huanhu Hospital 2012-06-01
Series:Chinese Journal of Contemporary Neurology and Neurosurgery
Subjects:
Muscular atrophy, spinal
Gene deletion
Gene amplification
Prenatal diagnosis
Online Access:http://www.cjcnn.org/index.php/cjcnn/article/view/336

Internet

http://www.cjcnn.org/index.php/cjcnn/article/view/336

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