Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

Abstract Background Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known. Methods We used in vivo confocal microscopy to compare the effects of inflammation in expe...

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Bibliographic Details
Main Authors: Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A. Gregson, Michael R Duchen, Kenneth J Smith
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Experimental autoimmune neuritis (EAN)
Phototoxic damage
In vivo
Confocal imaging
Mitochondrial
Small axons
Online Access:http://link.springer.com/article/10.1186/s12974-018-1094-8

Internet

http://link.springer.com/article/10.1186/s12974-018-1094-8

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