Development of Resistance to the Atypical Retinoid, ST1926, in the Lung Carcinoma Cell Line H460 Is Associated with Reduced Formation of DNA Strand Breaks and a Defective DNA Damage Response

Development of Resistance to the Atypical Retinoid, ST1926, in the Lung Carcinoma Cell Line H460 Is Associated with Reduced Formation of DNA Strand Breaks and a Defective DNA Damage Response

Atypical retinoids are potent inducers of apoptosis, but activation of the apoptotic pathway seems to be independent of retinoid receptors. Previous studies with a novel adamantyl retinoid, ST1926, have shown that apoptosis induction is associated with an early genotoxic stress. To better understand...

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Bibliographic Details
Main Authors: Valentina Zuco, Chiara Zanchi, Cinzia Lanzi, Giovanni L. Beretta, Rosanna Supino, Claudio Pisano, Marcella Barbarino, Romina Zanier, Federica Bucci, Concetta Aulicino, Paolo Carminati, Franco Zunino
Format: Article
Language:English
Published: Elsevier 2005-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
atypical retinoids
cellular resistance
apoptosis
DNA damage
stress response
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800880

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http://www.sciencedirect.com/science/article/pii/S1476558605800880

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