Sex differences in the polygenic architecture of hearing problems in adults

Sex differences in the polygenic architecture of hearing problems in adults

Abstract Background Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although several risk loci have been already identified, HP bio...

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Bibliographic Details
Main Authors: Flavio De Angelis, Oana A. Zeleznik, Frank R. Wendt, Gita A. Pathak, Daniel S. Tylee, Antonella De Lillo, Dora Koller, Brenda Cabrera-Mendoza, Royce E. Clifford, Adam X. Maihofer, Caroline M. Nievergelt, Gary C. Curhan, Sharon G. Curhan, Renato Polimanti
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genome Medicine
Subjects:
Hearing problems
Genome-wide association study
Ancestry; Polygenic risk scores
Transcriptomic regulation
Sex differences
Pleiotropy
Online Access:https://doi.org/10.1186/s13073-023-01186-3

Internet

https://doi.org/10.1186/s13073-023-01186-3

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