Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway

Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway

Rabies is an important neglected disease, characterized by invariably fatal encephalitis. Several studies focus on understanding the pathogenic mechanisms of the prototype lyssavirus rabies virus (RABV) infection, and little is known about the pathogenesis of rabies caused by other lyssaviruses. We...

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Bibliographic Details
Main Authors: Penelope Koraka, Byron E. E. Martina, Henk-Jan van den Ham, Fatiha Zaaraoui-Boutahar, Wilfred van IJcken, Jouke Roose, Geert van Amerongen, Arno Andeweg, Albertus D. M. E. Osterhaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
rabies
Duvenhage virus
genomics
pyroptosis
innate immune response
caspase-1
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00397/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00397/full

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