Targeting the conserved active site of splicing machines with specific and selective small molecule modulators

Targeting the conserved active site of splicing machines with specific and selective small molecule modulators

Abstract The self-splicing group II introns are bacterial and organellar ancestors of the nuclear spliceosome and retro-transposable elements of pharmacological and biotechnological importance. Integrating enzymatic, crystallographic, and simulation studies, we demonstrate how these introns recogniz...

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Bibliographic Details
Main Authors: Ilaria Silvestri, Jacopo Manigrasso, Alessandro Andreani, Nicoletta Brindani, Caroline Mas, Jean-Baptiste Reiser, Pietro Vidossich, Gianfranco Martino, Andrew A. McCarthy, Marco De Vivo, Marco Marcia
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-48697-0

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https://doi.org/10.1038/s41467-024-48697-0

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