Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples

Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples

Abstract Background Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations. However, mutation frequency alone is insufficient to identify cancer genes because mutability...

Полное описание

Библиографические подробности
Главные авторы: Ivan P. Gorlov, Claudio W. Pikielny, Hildreth R. Frost, Stephanie C. Her, Michael D. Cole, Samuel D. Strohbehn, David Wallace-Bradley, Marek Kimmel, Olga Y. Gorlova, Christopher I. Amos
Формат: Статья
Язык:English
Опубликовано: BMC 2018-11-01
Серии:BMC Bioinformatics
Предметы:
Catalog of somatic mutations in Cancer
COSMIC
Somatic mutations
Missense
Nonsense
Frameshift mutations
Online-ссылка:http://link.springer.com/article/10.1186/s12859-018-2455-0

Internet

http://link.springer.com/article/10.1186/s12859-018-2455-0

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