DNA replication stress is a determinant of chronological lifespan in budding yeast.

DNA replication stress is a determinant of chronological lifespan in budding yeast.

The chronological lifespan of eukaryotic organisms is extended by the mutational inactivation of conserved growth-signaling pathways that regulate progression into and through the cell cycle. Here we show that in the budding yeast S. cerevisiae, these and other lifespan-extending conditions, includi...

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Bibliographic Details
Main Authors: Martin Weinberger, Li Feng, Anita Paul, Daniel L Smith, Robert D Hontz, Jeffrey S Smith, Marija Vujcic, Keshav K Singh, Joel A Huberman, William C Burhans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1939877?pdf=render

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http://europepmc.org/articles/PMC1939877?pdf=render

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