The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic β Cells by Regulating MafA Expression

The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic β Cells by Regulating MafA Expression

Methylglyoxal, a major precursor of advanced glycation end products, is elevated in the plasma of patients with type 2 diabetes mellitus. Islet β-cell function was recently shown to be regulated by N6-methyladenosine (m6A), an RNA modification consisting of methylation at the N6 position of adenosin...

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Bibliographic Details
Main Authors: Yi Cheng, Xin-Ming Yao, Si-Min Zhou, Yue Sun, Xiang-Jian Meng, Yong Wang, Yu-Jie Xing, Shu-Jun Wan, Qiang Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
METTL3
methylglyoxal
N6-methyladenosine
pancreatic β cells
insulin secretion
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.910868/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.910868/full

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