The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling

The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling

Abstract Metabolic reprogramming is a hallmark of cancer, and the impact of lipid metabolism as a crucial aspect of metabolic reprogramming on clear cell renal cell carcinoma (ccRCC) progression has been established. However, the regulatory mechanisms underlying the relationship between metabolic ab...

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Bibliographic Details
Main Authors: Jian Shi, Daojia Miao, Qingyang Lv, Keshan Wang, Qi Wang, Huageng Liang, Hongmei Yang, Zhiyong Xiong, Xiaoping Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06090-7

Internet

https://doi.org/10.1038/s41419-023-06090-7

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