The effects of strain history on aortic valve interstitial cell activation in a 3D hydrogel environment

Aortic valves (AVs) undergo unique stretch histories that include high rates and magnitudes. While major differences in deformation patterns have been observed between normal and congenitally defective bicuspid aortic valves (BAVs), the relation to underlying mechanisms of rapid disease onset in BAV...

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Bibliographic Details
Main Authors: Toni M. West, Daniel P. Howsmon, Miles W. Massidda, Helen N. Vo, Athena A. Janobas, Aaron B. Baker, Michael S. Sacks
Format: Article
Language:English
Published: AIP Publishing LLC 2023-06-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0138030