Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses

Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses

We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects. We did not observe any polymorphisms associated with standard vaccine response outcomes (e.g., neutralizing antibody, T cell ELISPOT response, or...

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Bibliographic Details
Main Authors: Richard B. Kennedy, Iana H. Haralambieva, Inna G. Ovsyannikova, Emily A. Voigt, Beth R. Larrabee, Daniel J. Schaid, Michael T. Zimmermann, Ann L. Oberg, Gregory A. Poland
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
STING
smallpox vaccine
vaccinia
poxvirus
viral vaccines
immunogenetics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.567348/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.567348/full

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