Heterocycles 52: The Drug-Likeness Analysis of Anti-Inflammatory Thiazolo[3,2-b][1,2,4]triazole and Imidazo[2,1-b][1,3,4]thiadiazole Derivatives

Heterocycles 52: The Drug-Likeness Analysis of Anti-Inflammatory Thiazolo[3,2-b][1,2,4]triazole and Imidazo[2,1-b][1,3,4]thiadiazole Derivatives

Lipophilicity, a significant physicochemical parameter of bioactive molecules, along with absorption, distribution, metabolism, excretion parameters and toxicity risk, was investigated for 32 thiazolo[3,2-b][1,2,4]triazole and imidazo[2,1-b][1,3,4]thiadiazole derivatives with anti-inflammatory poten...

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Bibliographic Details
Main Authors: Anamaria Apan, Dorina Casoni, Denisa Leonte, Cristina Pop, Irina Iaru, Cristina Mogoșan, Valentin Zaharia
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceuticals
Subjects:
lipophilicity
RP-TLC
ADME properties
bioactivity
thiazolo[3,2-b][1,2,4]triazoles
imidazo[2,1-b][1,3,4]thiadiazoles
Online Access:https://www.mdpi.com/1424-8247/17/3/295

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https://www.mdpi.com/1424-8247/17/3/295

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