The dilemma of neuroprotection trials in times of successful endovascular recanalization

The dilemma of neuroprotection trials in times of successful endovascular recanalization

BackgroundThe “translational roadblock” between successful animal stroke studies and neutral clinical trials is usually attributed to conceptual weaknesses. However, we hypothesized that rodent studies cannot inform the human disease due to intrinsic pathophysiological differences between rodents an...

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Bibliographic Details
Main Authors: Antje Schmidt-Pogoda, Johannes Kaesmacher, Nadine Bonberg, Nils Werring, Jan-Kolja Strecker, Mailin Hannah Marie Koecke, Carolin Beuker, Jan Gralla, Raphael Meier, Heinz Wiendl, Heike Minnerup, Urs Fischer, Jens Minnerup
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Neurology
Subjects:
acute stroke
neuroprotection
mechanical thrombectomy
translational failures
infarct growth
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1383494/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2024.1383494/full

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