Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly

Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly

Abstract For successful infection of host cells and virion production, enveloped viruses, including Zika virus (ZIKV), extensively rely on cellular lipids. However, how virus protein–lipid interactions contribute to the viral life cycle remains unclear. Here, we employ a chemo-proteomics approach wi...

Full description

Bibliographic Details
Main Authors:	Sarah Goellner, Giray Enkavi, Vibhu Prasad, Solène Denolly, Sungmin Eu, Giulia Mizzon, Leander Witte, Waldemar Kulig, Zina M. Uckeley, Teresa M. Lavacca, Uta Haselmann, Pierre-Yves Lozach, Britta Brügger, Ilpo Vattulainen, Ralf Bartenschlager
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-42985-x

Similar Items

Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease
by: Shreyas Kaptan, et al.
Published: (2022-01-01)

Dimerization of the pulmonary surfactant protein C in a membrane environment.
by: Hanna Korolainen, et al.
Published: (2022-01-01)

A Novel System to Study Dengue Virus Replication Organelle Formation Independent from Viral RNA Replication
by: Berati Cerikan, et al.
Published: (2020-08-01)

Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin.
by: Giray Enkavi, et al.
Published: (2017-10-01)

Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions.
by: Matti Javanainen, et al.
Published: (2019-05-01)

The prM-independent packaging of pseudotyped Japanese encephalitis virus
by: Ju Young, et al.
Published: (2009-07-01)

Structural basis of actin monomer re-charging by cyclase-associated protein
by: Tommi Kotila, et al.
Published: (2018-05-01)

Replication-Independent Generation and Morphological Analysis of Flavivirus Replication Organelles
by: Sarah Goellner, et al.
Published: (2020-12-01)

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
by: Tommi Kotila, et al.
Published: (2019-11-01)

Mutation in West Nile Virus Structural Protein prM during Human Infection
by: Yaniv Lustig, et al.
Published: (2016-09-01)

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
by: Peter Nambala, et al.
Published: (2018-08-01)

C-terminal helical domains of dengue virus type 4 E protein affect the expression/stability of prM protein and conformation of prM and E proteins.
by: Wen-Yang Tsai, et al.
Published: (2012-01-01)

Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin
by: Solène Denolly, et al.
Published: (2023-10-01)

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways
by: Solène Denolly, et al.
Published: (2023-12-01)

Ultrastructural Characterization of Zika Virus Replication Factories
by: Mirko Cortese, et al.
Published: (2017-02-01)

Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody
by: Wirawan, Melissa, et al.
Published: (2021)

Development and biochemical characteristics of a monoclonal antibody against prM protein of Tembusu virus
by: Siming Zhu, et al.
Published: (2023-12-01)

The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity
by: Ge Li, et al.
Published: (2019-02-01)

An inactivated recombinant rabies virus displaying the Zika virus prM-E induces protective immunity against both pathogens.
by: Hongli Jin, et al.
Published: (2021-06-01)

The GET insertase exhibits conformational plasticity and induces membrane thinning
by: Melanie A. McDowell, et al.
Published: (2023-11-01)

Analysis of PRM1 and PRM2 Polymorphisms in Iranian Infertile Men with Idiopathic Teratozoospermia
by: Fatemeh Dehghanpour, et al.
Published: (2019-04-01)

Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation
by: Dominik Kiemel, et al.
Published: (2024-07-01)

Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence
by: Junyao Xiong, et al.
Published: (2022-06-01)

Antibodies against prM protein distinguish between previous infection with dengue and Japanese encephalitis viruses.
by: Sum Magdline, et al.
Published: (2002-05-01)

E and prM proteins of genotype V Japanese encephalitis virus are required for its increased virulence in mice
by: Shigeru Tajima, et al.
Published: (2019-11-01)

Characterization of the GXXXG motif in the first transmembrane segment of Japanese encephalitis virus precursor membrane (prM) protein
by: Wu Suh-Chin, et al.
Published: (2010-05-01)

Recombinant Measles AIK-C Vaccine Strain Expressing the prM-E Antigen of Japanese Encephalitis Virus.
by: Akira Higuchi, et al.
Published: (2016-01-01)

Nup98 Is Subverted from Annulate Lamellae by Hepatitis C Virus Core Protein to Foster Viral Assembly
by: Bertrand Boson, et al.
Published: (2022-04-01)

Building PRM in sub-Saharan Africa
by: Abena Yeboaa Tannor, et al.
Published: (2022-08-01)

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols
by: Calvin Dumesnil, et al.
Published: (2023-02-01)

The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity.
by: Natalia Freitas, et al.
Published: (2020-09-01)

Peralatan elektronik pengimejan resonans magnet (PRM) /
by: 332539 Roslinda Zainal
Published: (1997)

PRM navigation in trading drone and Gazebo simulation
by: Franklin Pineda Torres, et al.
Published: (2020-01-01)

Multi-molecular hyperspectral PRM-SRS microscopy
by: Wenxu Zhang, et al.
Published: (2024-02-01)

Path Planning for UAV Based on Improved PRM
by: Weimin Li, et al.
Published: (2022-10-01)

Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses
by: Franziska Woelfl, et al.
Published: (2020-04-01)

Differential Expressions of Protamine 1 (PRM1) and Protamine 2 (PRM2) Genes as Markers of Semen Quality in Pasundan Bulls
by: Santoso, et al.
Published: (2022-11-01)

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation
by: Vasudevan, Subhash G., et al.
Published: (2019)

The Safe Baculovirus-Based PrM/E DNA Vaccine Protected Fetuses against Zika Virus in A129 Mice
by: Hanul Choi, et al.
Published: (2021-04-01)

Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice
by: Takuya Inagaki, et al.
Published: (2021-10-01)