Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for the treatment of advanced HCC; however, the reported response rate to such a therapeutic is suboptimal (<3%). Piperine (PIP) is an alkaloid demonstrat...

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Bibliographic Details
Main Authors: Sulaiman S. Alhudaithi, Mohd Abul Kalam, Lama Binobaid, Raisuddin Ali, Mohammed M. Almutairi, Wajhul Qamar, Hessa Bin Hithlayn, Atheer Almutairi, Abdullah K. Alshememry
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Saudi Pharmaceutical Journal
Subjects:
Hepatocellular carcinoma
Sorafenib
Piperine
Poly (lactic-co-glycolic acid)
Emulsification-solvent-evaporation
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016424001142

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http://www.sciencedirect.com/science/article/pii/S1319016424001142

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