Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions

15-Lipoxygenase (15-LO)-induced oxidation of lipids in human LDL may be pro-atherogenic. However, the extent to which 15-LO promotes enzymatic oxidation of esterified (i.e., major) lipids in LDL may depend on various factors. Here, we show that overall, LDL lipid oxidation was favored with high acti...

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Bibliographic Details
Main Authors: Dagmar Heydeck, Joanne M. Upston, Helena Viita, Seppo Ylä-Herttuala, Roland Stocker
Format: Article
Language:English
Published: Elsevier 2001-07-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520315972