The neutrophil oxidant hypothiocyanous acid causes a thiol-specific stress response and an oxidative shift of the bacillithiol redox potential in Staphylococcus aureus

The neutrophil oxidant hypothiocyanous acid causes a thiol-specific stress response and an oxidative shift of the bacillithiol redox potential in Staphylococcus aureus

ABSTRACT During infections, Staphylococcus aureus is exposed to hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN), which are produced by the neutrophil myeloperoxidase as potent antimicrobial killing agents. In this work, we applied RNAseq transcriptomics, Brx-roGFP2 biosensor measurements,...

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Bibliographic Details
Main Authors: Vu Van Loi, Tobias Busche, Franziska Schnaufer, Jörn Kalinowski, Haike Antelmann
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
Staphylococcus aureus
HOSCN
transcriptome
MerA
bacillithiol
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03252-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03252-23

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