Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance

Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance

ABSTRACT Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different. The binding target of vancomycin is d-alanine-d-alanine (d-Ala-d-Ala), whereas that of β-lactam is penicillin-binding proteins (PBP...

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Bibliographic Details
Main Authors: Si Hyoung Park, Umji Choi, Su-Hyun Ryu, Han Byeol Lee, Jin-Won Lee, Chang-Ro Lee
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
antibiotic resistance
peptidoglycan hydrolase
peptidoglycan carboxypeptidase
DacA
β-lactam
vancomycin
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01734-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01734-22

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