Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts

Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts

The ubiquitous second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains. Phosphodiesterase subfamilies 4B and 4D are critically involved in the regulation of cAMP signaling in mammalian card...

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Bibliographic Details
Main Authors: Axel E. Kraft, Nadja I. Bork, Hariharan Subramanian, Nikoleta Pavlaki, Antonio V. Failla, Bernd Zobiak, Marco Conti, Viacheslav O. Nikolaev
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
cAMP
FRET
microdomain
phosphodiesterase
calcium cycling
Online Access:https://www.mdpi.com/2073-4409/13/6/476

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https://www.mdpi.com/2073-4409/13/6/476

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