Inhibition of valve mesenchymal stromal cell calcium deposition by bFGF through alternative polyadenylation regulation of the CAT gene

Inhibition of valve mesenchymal stromal cell calcium deposition by bFGF through alternative polyadenylation regulation of the CAT gene

Abstract Objective Calcific aortic valve disease (CAVD) is the leading cause of angina, heart failure, and death from aortic stenosis. However, the molecular mechanisms of its progression, especially the complex disease-related transcriptional regulatory mechanisms, remain to be further elucidated....

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Bibliographic Details
Main Authors: Jiajun Zhang, Jun Wu, Yuan Gao, Xingli Fan, Xiaohong Liu, Guanxin Zhang, Yangfeng Tang, Lin Han
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cardiovascular Disorders
Subjects:
Calcific aortic valve disease
Alternative polyadenylation
Catalase
bFGF
Online Access:https://doi.org/10.1186/s12872-024-03775-5

Internet

https://doi.org/10.1186/s12872-024-03775-5

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