Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis

Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing...

Full description

Bibliographic Details
Main Authors: Kyong-Oh Shin, Dae Hyun Ha, Jin Ock Kim, Debra A. Crumrine, Jason M. Meyer, Joan S. Wakefield, Yerin Lee, Bogyeong Kim, Sungeun Kim, Hyun-keun Kim, Joon Lee, Hyuck Hoon Kwon, Gyeong-Hun Park, Jun Ho Lee, Jihye Lim, Sejeong Park, Peter M. Elias, Kyungho Park, Yong Weon Yi, Byong Seung Cho
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
asc-exosomes
anti-inflammation
atopic dermatitis
restoration
skin barrier
lamella body
ceramides
Online Access:https://www.mdpi.com/2073-4409/9/3/680

Internet

https://www.mdpi.com/2073-4409/9/3/680

Similar Items