The Cytoplasmic Domain of proEGF Negatively Regulates Motility and Elastinolytic Activity in Thyroid Carcinoma Cells

The intracellular domains of the membrane-anchoring regions of some precursors of epidermal growth factor (EGF) family members have intrinsic biologic activities. We have determined the role of the human proEGF cytoplasmic domain (proEGFcyt) as part of the proEGF transmembrane-anchored region (proEG...

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Bibliographic Details
Main Authors: Aleksandra Glogowska, Janette Pyka, Astrid Kehlen, Marek Los, Paul Perumal, Ekkehard Weber, Sheue-yann Cheng, Cuong Hoang-Vu, Thomas Klonisch
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608801029