Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway

Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway

Abstract Background Hypoxia naturally happens in embryogenesis and thus serves as an important environmental factor affecting embryo development. Hif-1α, an essential hypoxia response factor, was mostly considered to mediate or synergistically regulate the effect of hypoxia on stem cells. However, t...

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Bibliographic Details
Main Authors: Xiaopeng Shen, Meng Li, Chunguang Wang, Zhongxian Liu, Kun Wu, Ao Wang, Chao Bi, Shan Lu, Hongan Long, Guoping Zhu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Biology
Subjects:
Hypoxia
Hif-1α
Wnt/β-Catenin
Mesendoderm differentiation
Ectoderm differentiation
Mouse embryonic stem cells
Online Access:https://doi.org/10.1186/s12915-022-01423-y

Internet

https://doi.org/10.1186/s12915-022-01423-y

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