Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics

Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics

Chronic pain is debilitating and represents a significant burden in terms of personal and socio-economic costs. Although opioid analgesics are widely used in chronic pain treatment, many patients report inadequate pain relief or relevant adverse effects, highlighting the need to develop analgesics w...

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Bibliographic Details
Main Authors: Andrea Bedini, Elisabetta Cuna, Monica Baiula, Santi Spampinato
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
opioid receptors
biased agonism
multidimensional signaling network
improved analgesics
Quantitative Systems Pharmacology
Online Access:https://www.mdpi.com/1422-0067/23/9/5114

Internet

https://www.mdpi.com/1422-0067/23/9/5114

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