Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on pancreatic adenocarcinoma cells CFPAC-1,1-(p-...

Full description

Bibliographic Details
Main Authors: Andrea Bistrović, Petra Grbčić, Anja Harej, Mirela Sedić, Sandra Kraljević-Pavelić, Sanja Koštrun, Janez Plavec, Damjan Makuc, Silvana Raić-Malić
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Purine
1,2,3-triazole
purinomimetic
non-small cell lung cancer A549
p38 MAPK
Online Access:http://dx.doi.org/10.1080/14756366.2017.1414807

Internet

http://dx.doi.org/10.1080/14756366.2017.1414807

Similar Items