Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia

Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia

Mutations in the presenilin genes PS1 and PS2, the major cause of familial Alzheimer's disease (FAD), are associated with alterations in Ca2+ signalling. In contrast to the majority of FAD-linked PS1 mutations, which cause an overload of intracellular Ca2+ pools, the FAD-linked PS2 mutation M23...

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Bibliographic Details
Main Authors: Marta Giacomello, Laura Barbiero, Giancarlo Zatti, Rosanna Squitti, Giuliano Binetti, Tullio Pozzan, Cristina Fasolato, Roberta Ghidoni, Paola Pizzo
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Neurobiology of Disease
Subjects:
Presenilin
Alzheimer's disease
Ca2+ homeostasis
Capacitative Ca2+ entry
Monozygotic twins
Fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002682

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http://www.sciencedirect.com/science/article/pii/S0969996104002682

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