Aspirin attenuates the detrimental effects of TNF-α on BMMSC stemness by modulating the YAP-SMAD7 axis

Aspirin attenuates the detrimental effects of TNF-α on BMMSC stemness by modulating the YAP-SMAD7 axis

Abstract Background Bone marrow mesenchymal stem cells (BMMSCs) are commonly used for cell transplantation to treat refractory diseases. However, the presence of inflammatory factors, such as tumour necrosis factor-alpha (TNF-α), at the transplantation site severely compromises the stemness of BMMSC...

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Bibliographic Details
Main Authors: Xudong Wang, Yong Liu, Shiyong Zhang, Linli Zheng, Yunze Kang, Puyi Sheng, Ziji Zhang
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Molecular Medicine
Subjects:
BMMSCs
Aspirin
TNF-α
Stemness
YAP
SMAD7
Online Access:https://doi.org/10.1186/s10020-024-00890-z

Internet

https://doi.org/10.1186/s10020-024-00890-z

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