Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

ABSTRACT Dengue virus (DENV) is a major human pathogen. An important pathogenicity factor is non-structural protein 1 (NS1) required for viral replication and secreted from infected cells. A clinical study indicated that the anti-parasitic drug ivermectin lowers NS1 blood levels without affecting vi...

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Bibliographic Details
Main Authors: Solène Denolly, Hongbo Guo, Miriam Martens, Anna Płaszczyca, Pietro Scaturro, Vibhu Prasad, Kessiri Kongmanas, Nuntaya Punyadee, Adisak Songjaeng, Dumrong Mairiang, Andreas Pichlmair, Panisadee Avirutnan, Ralf Bartenschlager
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
flavivirus
nuclear transport
protein secretion
nonstructural protein
host targeting therapy
glycoproteins
Online Access:https://journals.asm.org/doi/10.1128/mbio.01441-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01441-23

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