Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Abstract Background Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellular debris upon myelin damage or demyelination, a...

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Bibliographic Details
Main Authors: Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Neurodegeneration
Subjects:
Microglia
apoE isoforms
Demyelination
Lipid droplets
Remyelination
Online Access:https://doi.org/10.1186/s13024-022-00577-1

Internet

https://doi.org/10.1186/s13024-022-00577-1

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