Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents and identification of new anti-cancer targets. H...

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Bibliographic Details
Main Authors: Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
oleanolic acid
purine salvage pathway
hypoxanthine-guanine phosphoribosyltransferase
5′-nucleotidase
superoxide dismutase 1
macroautophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001248

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http://www.sciencedirect.com/science/article/pii/S2372770521001248

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