Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis

Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis

ObjectiveCD4+FoxP3+CD25+ regulatory T-cells (Tregs) are important for preventing tissue destruction. Here, we investigate the role of Tregs for protection against experimental arthritis by IFN-α.MethodsArthritis was triggered by intra-articular injection of methylated bovine serum albumin (mBSA) in...

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Bibliographic Details
Main Authors: Sudeep Chenna Narendra, Jaya Prakash Chalise, Sophie Biggs, Ulrich Kalinke, Mattias Magnusson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
interferon-alpha
regulatory T-cells
experimental arthritis
indoleamine 2,3-dioxygenase
kynurenine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00285/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00285/full

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