Chronic Nicotine Exposure Induces Murine Aortic Remodeling and Stiffness Segmentation—Implications for Abdominal Aortic Aneurysm Susceptibility

Aim: Arterial stiffness is a significant risk factor for many cardiovascular diseases, including abdominal aortic aneurysms (AAA). Nicotine, the major active ingredient of e-cigarettes and tobacco smoke, induces acute vasomotor effects that may temporarily increase arterial stiffness. Here, we inves...

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Main Authors: Markus U. Wagenhäuser, Isabel N. Schellinger, Takuya Yoshino, Kensuke Toyama, Yosuke Kayama, Alicia Deng, Sabina P. Guenther, Anne Petzold, Joscha Mulorz, Pireyatharsheny Mulorz, Gerd Hasenfuß, Wiebke Ibing, Margitta Elvers, Andreas Schuster, Anand K. Ramasubramanian, Matti Adam, Hubert Schelzig, Joshua M. Spin, Uwe Raaz, Philip S. Tsao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
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Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01459/full